I want to…
lose fat
Appetite, metabolism, and the drugs that actually move weight.
Draws from Growth & metabolic · Vitamins & cofactors — slice by mechanism in the library →
Ranked below. Evidence is the strength of the human science; Reported is how loud and consistent the community signal is — not proof. When they disagree, that gap is the point.
- 1TirzepatideDual GIP/GLP-1 agonist (fat loss)clinical
Dual incretin; ~20% weight loss in large trials.
Evidence10/10Reported8/10 - 2SemaglutideGLP-1 receptor agonist (fat loss / glycemic)clinical
Approved GLP-1; large, consistent trial data.
Evidence10/10Reported8/10 - 3RetatrutideTriple agonist (fat loss)clinical
Triple agonist; biggest loss seen in phase-2, not yet approved.
Evidence8/10Reported8/10 - 4CagrilintideLong-acting amylin analog (fat loss)clinical
Amylin analog; strongest paired with a GLP-1.
Evidence7/10Reported6/10 - 5MazdutideGLP-1/glucagon dual agonist (fat loss)clinical
GLP-1/glucagon; strong phase-2 data.
Evidence7/10Reported5/10 - 6TesamorelinGHRH analog (visceral fat)clinical
Approved specifically for visceral fat.
Evidence7/10Reported4/10 - 7SurvodutideGLP-1/glucagon dual agonist (fat loss / liver)clinical
GLP-1/glucagon; phase-2 data, less community use.
Evidence7/10Reported4/10 - 8Lipo-CLipotropic vitamin/amino blend (fat loss)community
Lipotropic injection; theory-driven, popular in clinics.
Evidence3/10Reported5/10 - 9AOD-9604GH fragment (fat loss)clinical
GH fragment — human fat-loss trials basically failed.
Evidence3/10Reported4/10 - 105-Amino-1MQNNMT inhibitor (small molecule, metabolic)animal-only
NNMT inhibitor; fat-loss buzz, animal data only.
Evidence2/10Reported4/10 - 11MOTS-cMitochondrial peptide (metabolic)animal-only
Metabolic/mito signal; animal data, endurance angle.
Evidence2/10Reported4/10
Not medical advice. Scores are our read of the evidence and the community signal, shown with the reason for each. How we rate evidence →